How to Train Your Mouse to Play with You Taming a mouse involves gaining their trust. By Lianne McLeod, DVM Lianne McLeod, DVM Lianne McLeod, DVM, is a small animal and exotic pet expert with over a decade of experience writing about veterinary care. After caring for animals in her veterinarian practice, Lianne went on to study biology and research water quality and chronic disease at the University of Saskatchewan. Learn more about The Spruce Pets' Editorial Process Updated on 07/22/25 Tips for Taking Care of a Pet Mouse 1:29 Taming pet mice is possible, although it requires patience. With time and consistency, you can gain the trust of your pet mouse. Handling pet mice can be tricky because they're small and quick. However, once tamed, they can be picked up, handled, and make great pets, even for kids. It's easiest to tame a mouse that's relaxed and comfortable in their surroundings. Starting with young mice makes the process easier. Use plenty of treats and work slowly, ensuring your mouse is comfortable with each step before moving to the next. Building Trust Taming a mouse is essentially gaining their trust. Your mouse must feel safe with you, despite your size. During training, avoid actions that might stress your pet mouse. You'll need to perform routine tasks like cleaning the cage, but remember to move slowly and gently to help gain your mouse's trust. Until tamed, your mouse might bite out of fear. If they bite, do not shake your hand or get angry, as this worsens the situation. Instead, step back and focus more on building trust. Important Information About Keeping Pet Mice Do not allow pet mice to run outside their cage unless they are tame. Chasing, catching, and returning them to the cage can scare them and foster fear of their owners. If you let your pet mouse outside the cage, ensure the area is well mouse-proofed since mice can squeeze through small cracks. Mice are typically kept in small groups of females because housing males and females together will result in baby mice. Males usually do best alone as they may fight with each other. Female mice bond well and this won't affect the taming process. A single mouse may be more stressed and difficult to tame than a female mouse with companions. Start Slowly When your mouse (or mice) arrive, they need time to settle in and start trusting you. This might be challenging for children eager to play with new pets, but patience pays off. Before interacting with your mouse: Allow a new mouse a few days to adjust to its new home, keeping maintenance and interaction to a minimum.Move slowly, speak softly, and limit interactions to when your mouse is awake. Do not wake sleeping mice, as it's not a good way to gain their trust.Start by sitting near the mouse's cage to get them used to your presence. Teach Your Mouse to Trust You After a few days, your mouse should stay calm when you enter the room and sit by their cage. Begin interacting with your new friend step by step to ensure bonding: Offer a treat (like sunflower seeds, small nuts, or raisins) when your mouse approaches the cage bars. Repeat until they come readily when they see you.Once comfortable taking treats through the bars, offer treats through an open cage door.When your mouse readily takes treats from your hand, place a treat on your open hand to encourage them to step up to retrieve it.When they voluntarily touch your hand, place the treat on your forearm to let your mouse climb onto your hand for the treat.Once your mouse is comfortable climbing onto your hand, gently scratch the sides and back of its head to mimic natural grooming. Pick Up Your Mouse the Right Way When your mouse is comfortable climbing onto your hand and allowing scratches, you can start taking them out to play. Mouse owners, especially young children, are eager to hold their pets. While holding is fine, remember some key points as you begin taming and handling. Never pick up a mouse by their tail; this can startle or hurt themIf your mouse isn't comfortable being held, gently guide them into a sideways cup. Once inside, tip the cup upright to carry the mouse, covering the opening to prevent escapesCarry a tame mouse cupped in your hand. Gently hold the scruff of loose neck skin to prevent escape, if needed.Use protective gloves to pick up an untamed mouse similarly to how you would handle a tamed one. Problems and Proofing Behavior Mice are naturally timid and can be startled by small noises or motion. They are small and quick, and can easily hide in inaccessible places. To keep your mouse safe outside the cage, create a play area they can't escape from. Build a circle of pillows, play in a small space like a bathroom, or use a solid-sided puppy corral. Once your mouse is safe, begin to "proof" their friendly behavior by gently challenging them with new sounds and people: Regularly play music near your mouse to show that the sound is not a threat.Have family members gently interact with the mouse to establish trust with multiple humans.Take your mouse (and their corral) into different environments to help them feel at home in new spaces. You may need to teach your mouse to trust young children, who are often louder and faster than adults or teens. If you suspect your pet is sick, call your vet immediately. For health-related questions, always consult your veterinarian, as they have examined your pet, know the pet's health history, and can make the best recommendations for your pet. Explore more: Small Pets Pet Mice